Number of pages: 6
Type of document: Journal Article
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More information on authors/freelancers connected to LBI :
Herman van Wietmarschen, PhD
Language of document: English
Title in English: Differences between serum polar lipid proﬁles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment
Abstract / summary in English:
As there are pharmacological differences between males and females, and glucocorticoid (GC) treatment is associated with increased cardiovascular mortality rate in rheumatoid arthritis (RA) patients, it is important to study serum polar lipid proﬁles of male and female patients in response to GC therapy. Gender differences may require an adjustment to the treatment strategy for a selection of patients.
Serum samples from 281 RA patients were analysed using a targeted lipidomics platform. The differences in GC use and gender on polar lipid proﬁles were cross sectionally examined by multiple linear regressions, while correcting for confounding factors.
Differences in polar lipids between GC users and non-GC users in females and males were merely restricted to lysophospholipids (lysophosphatidylcholines and lysophosphatidylethanolamines). Lysophospholipids in female patients treated with GCs were signiﬁcantly higher than female patients not treated with GCs (p = 6.0 E-6), whereas no signiﬁcant difference was observed in male GC users versus non-users (p = 0.397).
The lysophospholipid proﬁles in response to GCs were signiﬁcantly different between male and female RA patients, which may have implications for the cardiovascular risk of GC treatment.
Keywords in English: Gender difference, Lysophospholipid, Glucocorticoid, Rheumatoid arthritis