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Wijk, R. van, E. van Wijk, H. van Wietmarschen and J. van der Greef. 2014. Towards whole-body ultra-weak photon counting and imaging with a focus on human beings: A review. Journal of Photochemistry and Photobiology B: Biology. 139(5):39-46.


DOI: 10.1016/j.jphotobiol.2013.11.014

Type of document: Journal Article

More information on authors/freelancers connected to LBI :
Herman van Wietmarschen, PhD


Language of document: English

Title in English: Towards whole-body ultra-weak photon counting and imaging with a focus on human beings: A review

Abstract / summary in English:

For decades, the relationship between ultra-weak photon emission (UPE) and the health state of the body is being studied. With the advent of systems biology, attention shifted from the association between UPE and reactive oxygen species towards UPE as a reflection of changed metabolic networks. Essential for this shift in thinking is the development of novel photon count statistical methods that more reflect the dynamics of the systems organization. Additionally, efforts to combine and correlate UPE data with other types of measurements such as metabolomics be key to understand the complexity of the human body. This review describes the history and developments in the area of human UPE research from a technical – methodological perspective, an experimental perspective and a theoretical perspective. There is ample evidence that human UPE research will allow a better understanding of the body as a complex dynamical system. The future lies in the further development of an integrated UPE and metabolomics platform for a personalized monitoring of changes of the system towards health or disease.


Keywords in English: Ultra-weak photon emission; Biophoton; Systems biology; Reactive oxygen species; Human; Review
Towards whole-body ultra-weak photon counting and imaging with a focus on human beings: A review