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Klein-Laansma, C.T., J. Jansen, A.J.W. van Tilborgh and M. van Vliet. 2014. Evaluation of semi standardized individualized homeopathic treatment of 77 women with premenstrual disorders: observational study with 9 months follow-up. Alternative and Integrative Medicine. 3(3).

Number of pages: 10

DOI: 10.4172/2327-5162.1000164

Type of document: Journal Article

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Related to: PMS study

More information on authors/freelancers connected to LBI :
Marja van Vliet MSc


Language of document: English

Title in English: Evaluation of semi standardized individualized homeopathic treatment of 77 women with premenstrual disorders: observational study with 9 months follow-up

Abstract / summary in English:

Background: A large proportion (8-32%) of women in the fertile age suffers from premenstrual syndrome/ symptoms (PMS/S). Individualized homeopathy could offer relief and this should be further investigated. Semistandardized treatment with a limited number of homeopathic medicines and strictly defined prescription criteria could minimize prescription variability and increase reproducibility of the individualized treatment. Objective: In an extension of a previous pilot study, the utility of a semi-standardized algorithm with 11 medicines for individualized homeopathic treatment of women with PMS/S was further evaluated in daily practice with 9 months follow-up. Methods: Women completed symptom diaries during to 2 months to confirm PMS/S. Women diagnosed with PMS/S were included, consulted a homeopathic physician and completed a questionnaire with keynote symptoms for 11 homeopathic medicines. A computerized algorithm would process the answers and indicate the first homeopathic prescription. At follow-up visits change of prescription was possible. Main outcome measures were frequencies and proportions of (non-) algorithm-based prescriptions during the study and percentage of responders (≥ 50% drop in PMS scores). Secondary outcome measures were mean changes in PMS scores over time. Results: 77 women were included, 52 completed the study. The usefulness of the semi-standardized treatment protocol was confirmed. In 30 (57.5%) of the 52 analyzed women, PMS scores had dropped by ≥ 50%. For the estimated mean changes in PMS scores, it made no difference if women had used one or more of the 11 algorithm-based or also other homeopathic medicines (p=0.765). A significant association was found between symptom severity at baseline and changes in mean PMS scores (p<0.001). Conclusions: A semi-standardized individualized homeopathic treatment of women with PMS/S with 11 medicines proved useful in daily homeopathic practice, with improved reproducibility of individualized treatment. This treatment could be further tested in effectiveness research.


Keywords in English: premenstrual syndrome; premenstrual symptoms; homeopathy; individualized; personalized; semi-standardized
Evaluation of semi standardized individualized homeopathic treatment of 77 women with premenstrual disorders: observational study with 9 months follow-up