Mobile nav

Publicatie

Home >> Publicaties >> Publicatie
Fu, J., B.V.J. Cuppen, P.M.J. Welsing, H. van Wietmarschen, A.C. Harms, R. Berger, S. Koval, R.D.E. Fritsch-Stork, J.W.J. Bijlsma, T. Hankemeier, J. van der Greef, F.P.J.G. Lafeber. 2016. Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment. Inflammopharmacol. 24:397-402.

Aantal pagina's: 6

DOI: 10.1007/s10787-016-0284-1

Soort document: Journal Article

Download full text pdf, 480 kB; opent in nieuw venster

Meer over auteurs/freelancers verbonden aan het LBI :
Dr. Herman van Wietmarschen


Taal van het document: Engels

Title in English: Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment

Abstract / summary in English:

Objective
As there are pharmacological differences between males and females, and glucocorticoid (GC) treatment is associated with increased cardiovascular mortality rate in rheumatoid arthritis (RA) patients, it is important to study serum polar lipid profiles of male and female patients in response to GC therapy. Gender differences may require an adjustment to the treatment strategy for a selection of patients.

Methods
Serum samples from 281 RA patients were analysed using a targeted lipidomics platform. The differences in GC use and gender on polar lipid profiles were cross sectionally examined by multiple linear regressions, while correcting for confounding factors.

Results
Differences in polar lipids between GC users and non-GC users in females and males were merely restricted to lysophospholipids (lysophosphatidylcholines and lysophosphatidylethanolamines). Lysophospholipids in female patients treated with GCs were significantly higher than female patients not treated with GCs (p = 6.0 E-6), whereas no significant difference was observed in male GC users versus non-users (p = 0.397).

Conclusion
The lysophospholipid profiles in response to GCs were significantly different between male and female RA patients, which may have implications for the cardiovascular risk of GC treatment.
 


Keywords in English: Gender difference, Lysophospholipid, Glucocorticoid, Rheumatoid arthritis
Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment